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KMID : 0848020010040020167
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Journal of Korean Breast Cancer Society
2001 Volume.4 No. 2 p.167 ~ p.171
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Prognosis of GLUT1 Expression in Human Breast Carcinoma
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안형준/Hyung Joon Ahn
이길연/이상목/고석환/홍성화/오수명/김윤화/Kil Yeon Lee/Sang Mok Lee/Suck Hwan Koh/Sung Wha Hong/Soo Myung Oh/Youn Wha Kim*
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Abstract
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Purpose: An increase of glucose uptake and glycolytic metabolism has been reported in malignant cells as compared with normal cells and tissues. We hypothesized that human erythrocyte glucose transporter-1 (GLUT1) expression is increased
in
breast carcinoma and may be correlated with long term clinical outcome.
Methods: Two hundred ninety formalin fixed, paraffin embedded sections of infiltrating ductal carcinomas of the breast were immunostained with anti-GLUT1.
Results: Among the known clinicopathological prognostic factors, GLUT1 expression was correlated positively with histological grade (p=0.000) and tumor size (p=0.003). In a multivariate analysis, lymph node involvement and GLUT1 expression
were
statistically significant prognostic factors. The cummulative survival rates of GLUT1 expression and LN involvement were statistically significant (p=0.0061, p=0.0009) respectively. Our results suggest that 1) GLUT1 expression is correlated with
histological grade and tumor size, and 2) GLUT1 expression correlates with a poorer prognosis in patients with infiltrating ductal carcinoma of the breast.
Conclusion: The results of our study suggest that immunohistochemical staining of GLUT1 expression is strongly associated with neoplastic progression in breast carcinoma, and that GLUT1 expression has value in estimating the prognosis of
patients
with breast carcinoma.
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KEYWORD
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